Adsorption of pyrantel pamoate on mercury from aqueous solutions: Studies by stripping voltammetry

Adsorption and electrochemical reduction of pyrantel pamoate are studied in Britton Robinson buffer medium at hanging mercury drop electrode (HMDE) by Adsorptive Stripping Voltammetric technique. The peak current shows a linear dependence with the drug concentration over the range 250 ng mL−1 to 64 μg mL−1. Applicability to assay the drug in urine samples is illustrated in the concentration range 5–20 μg mL−1.

Cyclic voltammetry of pyrantel pamoate after pre-concentration.Figure optionsDownload high-quality image (33 K)Download as PowerPoint slideResearch highlights
► The method has distinct advantages over other existing methods in terms of sensitivity, time saving and delectability.
► Can be applied to the detection of pyrantel in different pharmaceutical dosage forms.
► No sophisticated instrumentation is required.
► Good analytical alternative in comparison to spectrophotometric and chromatographic methods for determining pyrantel pamoate.
► Can be adopted for pharmacokinetic studies as well as for quality control in pharmaceutical laboratories.