Strategies to control the particle size distribution of poly-ε-caprolactone nanoparticles for pharmaceutical applications

PCL mean particle size (dm) versus the flow rate (FR) for Mw=14,000, initial polymer concentrations cPCL0=10 mg/ml and for water to acetone flow rate ratio W/A = 1 (□), W/A = 2 (○), W/A = 3 (▵), W/A = 4 (▿).