کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
611931 880688 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cathodic adsorptive stripping voltammetric studies on lamivudine: An antiretroviral drug
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی شیمی کلوئیدی و سطحی
پیش نمایش صفحه اول مقاله
Cathodic adsorptive stripping voltammetric studies on lamivudine: An antiretroviral drug
چکیده انگلیسی

The electrochemical reduction and adsorption of lamivudine, a systemic antiviral drug, were studied in a phosphate buffer medium at a hanging mercury drop electrode (HMDE). Cyclic voltammetry studies showed one well-defined reduction peak in the potential range from −1.2 to −1.8 V−1.8 V under different pH conditions, but the best results were obtained at pH 3.4. The reduction was irreversible and exhibited diffusion-controlled adsorption. The response was evaluated with respect to preconcentration time, pH effect, accumulation potential, accumulation time, and scan rate. The number of electrons transferred in the reduction process was calculated and the probable reduction mechanism was proposed. A systemic study of the experimental parameters that affect the square-wave stripping response was carried out and experimental conditions were optimized.

The electrochemical reduction and adsorption of lamivudine, a systemic antiviral drug, were studied in phosphate buffer medium at a hanging mercury drop electrode (HMDE). The response was evaluated with respect to preconcentration time, pH effect, accumulation potential, accumulation time, and scan rate.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Colloid and Interface Science - Volume 313, Issue 1, 1 September 2007, Pages 254–260
نویسندگان
, , ,