کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
611984 880689 2008 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Interfacial properties of Pluronics and the interactions between Pluronics and cholesterol/DPPC mixed monolayers
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی شیمی کلوئیدی و سطحی
پیش نمایش صفحه اول مقاله
Interfacial properties of Pluronics and the interactions between Pluronics and cholesterol/DPPC mixed monolayers
چکیده انگلیسی

Pluronics are triblock copolymers of poly(ethylene oxide)–poly(propylene oxide)–poly(ethylene oxide) (PEO–PPO–PEO) with wide range of hydrophilic–lipophilic balance. In order to investigate the relationship between the chemical structures of Pluronics and the interfacial properties at the air–water interface by monolayer techniques, Pluronics L61, P65, F68, P84, P123, L35, and P105 were selected. Since cholesterol influenced substantially the molecular packing stage and the characteristics of cell membranes, the interactions between Pluronics and model cell membranes in the absence and presence of cholesterol were compared. The results of π–Aπ–A isotherms and surface elasticities of Pluronic monolayers indicated that the first and second transition like stage were mainly affected by the numbers of EO and PO monomers, respectively. Pluronics with higher hydrophobicities demonstrated larger surface activities and penetration abilities to dipalmitoylphosphatidylcholine (DPPC) monolayers, which might be due to hydrophobic interactions and van der Waals forces. In the presence of cholesterol, hydrogen bonding effects was supposed to exist between the 3β-hydroxy group of cholesterol and ether oxygen of PEO chains, which led Pluronic F68, with the longest PEO chain herein, to exhibit significantly higher penetration ability. Our findings proposed a theoretical basis for selection of optimized drug carriers and the starting point for further investigations.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Colloid and Interface Science - Volume 322, Issue 1, 1 June 2008, Pages 263–273
نویسندگان
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