Phase behavior of mixed solution of a glycerin-modified cationic surfactant and an anionic surfactant

The phase behavior of mixed solution of newly synthesized monoglycerylcetyldimethylammonium chloride (MGCA) and sodium octyl sulfate (SOS) in water was investigated by cryo-transmission electron microscopy (cryo-TEM), dynamic light scattering (DLS), differential scanning calorimetry (DSC), and fluorescence polarizing for evaluation of the microviscosity of bilayers. No precipitate was observed in the mixed solution except at concentrations below 20 mM over all mixing ratios, and stable vesicles were formed in a considerably wide range of mixing ratio, even at the equimolar ratio. Vesicles formed in aqueous 1/1 MGCA/SOS mixture were found to exhibit no phase transition, and fluorescence polarizing measurements showed that the vesicle bilayers have a high fluidity. This flexibility allows the bilayers to have a spontaneous curvature, and thus vesicles rather than flat lamellae can be stabilized in the mixture even at the equimolar ratio. In addition, because the glycerin group of MGCA interacts strongly with water, the hydration repulsion contributes to prevent the bilayers consisting of MGCA and SOS from adhering and flocculating even though the charge neutralization between MGCA and SOS occurs at the equimolar ratio.

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