White-nose syndrome is likely to extirpate the endangered Indiana bat over large parts of its range

► White-nose syndrome affects the most sensitive life stage, adult winter survival. ► We determined for the endangered Indiana bat risk of extirpation from white-nose syndrome. ► Indiana bats will persist for at least the next half-century, albeit at greatly reduced numbers. ► Whether the species becomes accustomed to the disease will determine the long-term fate of this species.