Viral receptors of the gut: vector-borne viruses of medical importance

â¿¢Molecular information on gut receptors for mosquito-borne and tick-borne arboviruses.â¿¢Arboviruses interact with various putative receptors on the arthropod gut.â¿¢Gut receptors are good candidates for developing transmission-blocking vaccines.

Arthropods transmit several medically important arboviruses that cause diseases in humans. Therapeutic strategies to treat or prevent diseases transmitted by the arthropods are limiting. Understanding the role of arthropod gut receptors in the interactions with various arboviruses would provide important means for the development of a strong anti-vector vaccine. In this review, we summarize some of the potential findings in the field of arthropod gut receptors for tick-borne or mosquito-borne viruses and discuss their relevance in the development of a broad-spectrum transmission-blocking vaccine to treat or control various diseases caused by arboviruses.

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