Chemical dispersants used in the Gulf of Mexico oil crisis are cytotoxic and genotoxic to sperm whale skin cells

- First study to measure chromosomal chemical dispersant toxicity in marine mammal cells.
- Corexit 9500 is cytotoxic and genotoxic in sperm whale skin cells.
- Corexit 9527 is cytotoxic and genotoxic in sperm whale skin cells.
- Corexit 9527 was less cytotoxic, but more genotoxic than Corexit 9500.

The 2010 Deepwater Horizon oil rig explosion in the Gulf of Mexico drew attention to the need for toxicological studies of chemical dispersants. We are still learning the effects these spills had on wildlife. Little is known about the toxicity of these substances in marine mammals. The objective of this study was to determine the toxicity of the two dispersants (Corexit 9500 and 9527). Corexit 9500 and 9527 were both cytotoxic to sperm whale skin fibroblasts. Corexit 9527 was less cytotoxic than 9500. S9 mediated metabolism did not alter cytotoxicity of either dispersant. Both dispersants were genotoxic to sperm whale skin fibroblasts; S9 mediated metabolism increased Corexit 9527 genotoxicity.