Chronic nanoparticulate silver exposure results in tissue accumulation and transcriptomic changes in zebrafish

► Chronic exposure to AgNP resulted in significant tissue accumulation in both gill and eviscerated carcass tissue. ► Tissue accumulation persisted for up to 4 days after the silver was removed from the system. ► There were no observable effects on gill histopathology. ► The high concentration of AgNP resulted in significant alterations in global gene expression profiles.