Experimental mixtures of Phthorimaea operculella granulovirus isolates provide high biological efficacy on both Phthorimaea operculella and Tecia solanivora (Lepidoptera: Gelechiidae)

► The genotypic heterogeneity of mixtures of virus isolates determined their efficacy. ► All the mixtures tested had a great efficacy on both Phthorimaea operculella and Tecia solanivora. ► The mixtures always showed higher pathogenicity than each constitutive isolates alone. ► Successive passages on hosts did not affect efficacy of virus mixtures over time.