کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6422032 | 1340595 | 2012 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Stability analysis of a model for HBV infection with cure of infected cells and intracellular delay
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
ریاضیات
ریاضیات کاربردی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Stability analysis of a model for HBV infection with cure of infected cells and intracellular delay Stability analysis of a model for HBV infection with cure of infected cells and intracellular delay](/preview/png/6422032.png)
چکیده انگلیسی
A viral infection model of HBV infection of hepatocytes with “cure” of infected cells and intracellular delay is studied. The delay corresponds to the time necessary for a newly produced virion to become infectious particles. We prove that the stability is completely determined by the basic reproductive number R0(Ï). If R0(Ï)â¤1, the infection-free steady state is globally asymptotically stable. If R0(Ï)>1 then infection-free steady state becomes unstable and a unique infected steady state exists and is locally asymptotically stable. On the other hand, we derive sufficient conditions for the global asymptotic stability of the infected steady state. Numerical simulations are presented to illustrate the results.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Mathematics and Computation - Volume 219, Issue 1, 15 September 2012, Pages 389-398
Journal: Applied Mathematics and Computation - Volume 219, Issue 1, 15 September 2012, Pages 389-398
نویسندگان
Cruz Vargas-De-León,