A mild and convenient protocol for the conversion of toxic acid red 37 into pharmacological (antibiotic and anticancer) nominees: Organopalladium architectures

Diverse applications of azo dyes in textiles, paper, leather, cosmetics, pharmaceutical, and food industries along with their deleterious impacts on human beings and aquatic life have raised urgent calls for the treatment of effluent containing azo dyes to remove them or convert them into useful and safe products. This inspires us to modulate acid red 37 to acid red Schiff bases (ARSBs), which were further palladinated to yield monopalladated products (Pd(II)-ARSBs) with an emphasis to obtain new pharmacological (antibiotic and anticancer) candidates. These new cyclopalladated complexes were structurally characterized and pharmacologically evaluated as well for their in vitro antimicrobial, against a common panel of pathogenic G+ and G− bacterial and fungal strains, and anticancer activities against human breast carcinoma (MCF-7) cell lines.

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