The building blocks of successful translation of proteomics to the clinic

- Many omics-based tests are proposed in the literature but very few make it to the clinic.
- First two multiplexed tests using selective reaction monitoring (SRM-MS) mass spectrometry in the blood have entered clinical practice.
- Development of both tests used the same strategy from discovery through clinical use.
- This strategy succeeded in two different applications: lung cancer and pre-term birth.
- We present here that strategy as a roadmap for development of future tests for other indications.