کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6487332 1416321 2018 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Engineering microbial communities using thermodynamic principles and electrical interfaces
ترجمه فارسی عنوان
جوامع میکروبی مهندسی با استفاده از اصول ترمودینامیکی و رابط های الکتریکی
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی
Microbial communities present the next research frontier. We argue here that understanding and engineering microbial communities requires a holistic view that considers not only species-species, but also species-environment interactions, and feedbacks between ecological and evolutionary dynamics (eco-evo feedbacks). Due this multi-level nature of interactions, we predict that approaches aimed soley at altering specific species populations in a community (through strain enrichment or inhibition), would only have a transient impact, and species-environment and eco-evo feedbacks would eventually drive the microbial community to its original state. We propose a higher-level engineering approach that is based on thermodynamics of microbial growth, and that considers specifically microbial redox biochemistry. Within this approach, the emphasis is on enforcing specific environmental conditions onto the community. These are expected to generate higher-level thermodynamic bounds onto the system, which the community structure and function can then adapt to. We believe that the resulting end-state can be ecologically and evolutionarily stable, mimicking the natural states of complex communities. Toward designing the exact nature of the environmental enforcement, thermodynamics and redox biochemistry can act as coarse-grained principles, while the use of electrodes - as electron providing or accepting redox agents - can provide implementation with spatiotemporal control.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Biotechnology - Volume 50, April 2018, Pages 121-127
نویسندگان
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