Prosthetic gene networks as an alternative to standard pharmacotherapies for metabolic disorders

- The global epidemic of interrelated metabolic diseases is dramatically increasing.
- Closed-loop prosthetic gene circuits may be used for the treatment of metabolic disorders.
- Prosthetic networks could functionally integrate and interface with host cell metabolism.
- Prosthetic networks could self-sufficiently monitor disease states and automatically provide therapy.
- Prosthetic networks may compare favourably with classical pharmacotherapy.