Alternative modulation of protein-protein interactions by small molecules

- Protein-protein interactions can be modulated by more than orthosteric disruption.
- Modulator categories: 'orthosteric versus allosteric' and 'disrupting versus stabilising'.
- Interfacial binders exert secondary effects.
- Non-competitive modulation is a way around low affinity molecules.
- Non-competitive modulators require tailored screening strategies.