Metabolism and epigenetics: a link cancer cells exploit

- Oncogenic and microenvironmental stimuli rewire metabolism in cancer cells.
- Many chromatin-modifying enzymes rely on metabolites as cofactors or substrates.
- Histone acetylation is sensitive to acetyl-CoA levels, and linked to growth and proliferation.
- Histone methylation is sensitive to the methyl donor S-adenosylmethionine.