A nexus for cellular homeostasis: the interplay between metabolic and signal transduction pathways

- Signaling networks sense intracellular and extracellular cues to maintain homeostasis.
- PI3K/AKT and Ras/ERK signaling induces anabolic reprogramming.
- mTORC1 is a master node of signaling integration that promotes anabolism.
- AMPK and SIRT1 fine tune signaling networks in response to energetic status.