The widespread role of non-enzymatic reactions in cellular metabolism

- Non-enzymatic reactions are widespread and integral part of metabolism.
- Non-enzymatic metabolic reactions occur either spontaneously or small molecule catalyzed.
- They subdivide between broad/unspecific, and specific reactions that contribute to metabolism.
- Specific reactions occur both, exclusively non-enzymatically or parallel to enzymes.
- Non-enzymatic reactions affect drug design and network reconstruction.