Systems glycobiology for glycoengineering

- Glycosylation is a major concern in pharmaceutical production.
- Computational models facilitate the in-silico design of glycosylation.
- Parameter calibration is required before models can be used for in-silico design.
- Glycosylation models can be linked to metabolic models to simulate fed-batch growth.
- Parameter-free and constraints-based approaches are promising future options.