Recent advances in genome-based polyketide discovery

- Recent in silico and experiment-guided genome mining strategies are highlighted.
- Homology-based and genome sequencing-independent approaches to target polyketides are described.
- Strategies for polyketide discovery guided by synthetic biology and metabolic/genetic engineering.
- Complementing the advances in genome mining, next generation analytical approaches are discussed.
- Pathogens, mutualists, anaerobes and uncultured bacteria are biosynthetically prolific.