Shear-induced platelet activation and its relationship with blood flow topology in a numerical model of stenosed carotid bifurcation

Study of the local hemodynamics in a realistic image-based model of stenosed carotid artery. ► Influence of the stenotic disturbed flow on transport and activation of platelets. ► Flow-induced level of platelet activation predicted by adopting a cumulative blood damage model. ► Stenosis enhances the risk for flow-induced activation of platelet. ► Helical flow patterns act as protective factors against platelet activation.