کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
654757 885269 2008 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Generalized Fourier series solution of equations governing molecular-motor-assisted transport of adenoviral vectors in a spherical cell
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی جریان سیال و فرایندهای انتقال
پیش نمایش صفحه اول مقاله
Generalized Fourier series solution of equations governing molecular-motor-assisted transport of adenoviral vectors in a spherical cell
چکیده انگلیسی

This paper presents an analytical solution of one-dimensional transient molecular-motor-assisted transport equations that describe transport of adenoviruses in a spherical cell. The model of intracellular trafficking of adenoviruses is based on molecular-motor-assisted transport equations suggested by Smith and Simmons [D.A. Smith, R.M. Simmons, Models of motor-assisted transport of intracellular particles, Biophysical Journal 80 (2001) 45–68.]. These equations are presented in spherical coordinates and extended by accounting for the random component of motion of viral particles bound to filaments. This random component is associated with the stochastic nature of molecular motors responsible for the locomotion of viral particles bound to filaments. Utilizing the method of separation of variables, a generalized Fourier series solution for this problem is obtained. The solution uses two different orthogonal sets of eigenfunctions to represent the concentration of free viral particles transported by diffusion and the concentration of microtubule-bound viral particles transported by kinesin-family molecular motors away from the cell nucleus. Binding/detachment kinetic processes between the viral particles and microtubules are specified by first rate reaction constants; these lead to coupling between the two viral concentrations. The obtained solution simulates viral transport between the cell membrane and cell nucleus during initial stages of viral infection.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Communications in Heat and Mass Transfer - Volume 35, Issue 4, April 2008, Pages 395–403
نویسندگان
, ,