کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6590765 456861 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lactose microparticle formation from finely atomised droplets
ترجمه فارسی عنوان
تشکیل میکروارگال لاکتوز از قطرات ریز شکسته
کلمات کلیدی
بارش ضدخش میکروسپور، لاکتوز، قطره های اتمیزه مونودیسپرس،
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
چکیده انگلیسی
The antisolvent vapour precipitation method has been proven to produce uniformly sized lactose microspheres from a single droplet (~1.2 mm diameter) at atmospheric pressure. These types of particles have potential applications in the pharmaceutical industry, especially due to their high solubility and dissolution rate. This article discusses the possibility of using antisolvent vapour precipitation for finely atomised droplets. Microspheres in the sub-micron scale (~0.4 μm diameter) have been produced, much smaller than those obtained from the single droplet method (~1.0 μm diameter). These particles were not affected by ethanol exposure time (up to 60 s) or drying temperature (up to 190 °C), though the structure was related to the absolute humidity of ethanol. We hypothesise a self-emulsified, two-phase system in the droplet could be the responsible for the formation of the porous and bicontinuous structure as an increase in the absolute humidity resulted in a shrinkage phenomenon which led to the microsphere formation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemical Engineering Science - Volume 122, 27 January 2015, Pages 395-402
نویسندگان
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