Redirecting carbon flux into malonyl-CoA to improve resveratrol titers: Proof of concept for genetic interventions predicted by OptForce computational framework

► We perform specific genetic alterations to improve malonyl-CoA availability in Escherichia coli. ► Genetic interventions predicted by OptForce increase carbon flux through malonyl-CoA. ► We improve titers of plant natural product, resveratrol by ∼60%. ► We find optimal temperature for this fermentation along with the over-expressions.