Systematic design of supersaturation controlled crystallization processes for shaping the crystal size distribution using an analytical estimator

▸ An analytical CSD estimator is derived for crystallisation at constant supersaturation. ▸ A supersaturation controlled crystallisation design parameter is introduced. ▸ Design parameter is determined via optimisation for target CSD shape. ▸ Combined supersaturation and seed recipe optimisation is proposed for CSD shaping. ▸ Analytical estimator is used to evaluate and design dynamic seeding procedures.