Exploiting polymorphism in the purity enhancement of lincomycin hydrochloride

► Polymorphism is exploited to enhance the purity of lincomycin hydrochloride. ► Polymorph I can accommodate more lincomycin B hydrochloride than polymorph II. ► A particular facet of polymorph I still remains in polymorph II. ► The content of residual facet of polymorph I and the product purity are correlated.