In-situ monitoring and characterization of plug flow crystallizers

► Use of plug flow crystallization system to anti-solvent crystallization of benzoic acid from aqueous ethanol solutions. ► Stable operation was observed with rapid attainment of steady state. ► A simple initial screening methodology for potential systems for use in plug flow crystallizers is outlined. ► PAT was successfully utilized to monitor and characterize plug flow crystallizations in situ. ► Final CSD at fixed feed concentration was significantly altered by manipulating anti-solvent and feed flow rates.