Monitoring of the combined cooling and antisolvent crystallisation of mixtures of aminobenzoic acid isomers using ATR-UV/vis spectroscopy and FBRM

► Monitoring multicomponent crystallisation using ATR-UV/vis and FBRM. ► Monitoring of combined cooling and antisolvent crystallisation of mixtures of isomers. ► Development of nonlinear calibration for ATR-UV/vis for the multicomponent system. ► Use of combined PCA-ANN approach for nonlinear calibration model.