کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6594431 1423665 2018 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Autocatalytic synthesis of 3-ethyl-3-hydroxy-indole-2-ones and their neuroprotection and antitumor activities' evaluation
ترجمه فارسی عنوان
سنتز اتوکاتالیستی 3-اتیل-3-هیدروکسی-اندول-2-آن ها و ارزیابی فعالیت های عصبی و فعالیت ضد تومور
کلمات کلیدی
ایاتین، 3-اتیل-3-هیدروکسی-اندول-2-یک، ضد تومور، محافظت از عصب
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
چکیده انگلیسی
In this study, a series of 3-ethyl-3-hydroxy-indole-2-ones were synthesized through the addition reaction of Et2Zn and N-substituted isatin by an autocatalytic process. The synthesized compounds were characterized by NMR spectroscopy and mass spectrometry, and the reaction mechanism was discussed. The antitumor and neuroprotection activities of these compounds were evaluated. The results showed that several compounds display protection activity on H2O2-induced apoptosis of PC12 cells, which are more effective than that of (±)-α-tocopherol Vitamin E (VE). Moreover, these compounds also show antitumor activity against A549 and P388 cell lines.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Comptes Rendus Chimie - Volume 21, Issue 5, May 2018, Pages 471-474
نویسندگان
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