Moisture soft sensor for batch fluid bed dryers: A practical approach

A mathematical model for online prediction of pharmaceutical product moisture in fluid-bed-dryers is proposed. The model combines thermodynamics principles (heat absorption, evaporation rates, humidity impact) with historical data to provide moisture predictions as accurate as 0.16% in RMSEP. Two applications are end-point detection for stopping, and process knowledge in a mathematical format that can be used for process optimization and closed-loop control. 211