Transient spreading and swelling behavior of a gel deploying an anti-HIV topical microbicide

► We study the elasto-lubrication flow of a Carreau-like fluid. ► This is a model for a microbicide drug delivery vehicle, intended to coat the vagina. ► Mass transfer occurs due to inhomogeneous dilution of the gel by vaginal fluid. ► Local dilution of gel alters local rheological properties. ► A boundary flux model based upon the elevated pressures in cells is implemented.