Effect of impeller design on homogeneity, size and strength of pharmaceutical granules produced by high-shear wet granulation

- Methylene blue was used as an inert tracer in lactose granulation experiments.
- Impeller design had a significant impact on high shear granulation.
- High temperature flexible beater was the best in terms of yield and homogeneity.
- Highest granule strength was achieved using a stainless steel power whisk.