Irbesartan drug formulated as nanocomposite particles for the enhancement of the dissolution rate

► IBS composite nanoparticles were prepared by using PVP/SDS as the stabilizer. ► PVP/SDS could significantly decrease the particle size to 55 nm. ► The stability of drug nanoparticles is greatly enhanced by PVP/SDS. ► The composite nanoparticles showed a significant enhancement in dissolution rate.