کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
672342 887498 2008 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Engineering of drug nanoparticles by HGCP for pharmaceutical applications
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی جریان سیال و فرایندهای انتقال
پیش نمایش صفحه اول مقاله
Engineering of drug nanoparticles by HGCP for pharmaceutical applications
چکیده انگلیسی

This paper reviews our work on the fundamental principles of high gravity controlled precipitation (HGCP) technology, and its applications in the production of drug nanoparticles, which was carried out in a rotating packed bed (RPB). Several kinds of drug nanoparticles with narrow particle size distributions (PSDs) were successfully prepared via HGCP, including the 300-nm Cefuroxime Axetil (CFA) particles, 200–400-nm cephradine particles, 500-nm salbutamol sulfate (SS) particles (100 nm in width), and 850-nm beclomethasone dipropionate (BDP) particles, etc. Compared to drugs available in the current market, all the drug nanoparticles produced by HGCP exhibited advantages in both formulation and drug delivery, thus improving the bioavailability of drugs. HGCP is essentially a platform technology for the preparation of poorly water-soluble drug nanoparticles for oral and injection delivery, and of inhalable drugs for pulmonary delivery. Consequently, HGCP offers potential applications in the pharmaceutical industry due to its cost-effectiveness, efficient processing and the ease of scaling-up.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Particuology - Volume 6, Issue 4, August 2008, Pages 239–251
نویسندگان
, , , ,