کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6802942 | 1433518 | 2018 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
White matter hyperintensities and vascular risk factors in monozygotic twins
ترجمه فارسی عنوان
هیپرپنوتیزم ماده سفید و عوامل خطر عروقی در دوقلوهای مونوزیگوت
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کلمات کلیدی
کمبود شدید ماده سفید، عوامل خطر عروقی، دوقلوهای مونوزیگوت،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Cerebral white matter hyperintensities (WMHs) have been associated with vascular risk factors, both of which are under genetic influence. We examined in a monozygotic twin sample whether the association between vascular risk and WMHs is influenced by overlapping genetic factors. We included 195 cognitively normal monozygotic twins (age = 70 ± 7 years), including 94 complete pairs. Regional WMH load was estimated using an automated algorithm. Vascular risk was summarized with the Framingham score. The within-twin pair correlation for total WMHs was 0.76 and for Framingham score was 0.77. Within participants, Framingham score was associated with total and periventricular WMHs (r = 0.32). Framingham score in 1 twin was also associated with total WMHs in the co-twin (r = 0.26). Up to 83% of the relation between both traits could be explained by shared genetic effects. In conclusion, monozygotic twins have highly similar vascular risk and WMH burden, confirming a genetic background for these traits. The association between both traits is largely driven by overlapping genetic factors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 66, June 2018, Pages 40-48
Journal: Neurobiology of Aging - Volume 66, June 2018, Pages 40-48
نویسندگان
Mara ten Kate, Carole H. Sudre, Anouk den Braber, Elles Konijnenberg, Michel G. Nivard, M. Jorge Cardoso, Philip Scheltens, Sébastien Ourselin, Dorret I. Boomsma, Frederik Barkhof, Pieter Jelle Visser,