کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6803105 | 1433522 | 2018 | 37 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The FBN rat model of aging: investigation of ABR waveforms and ribbon synapse changes
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Age-related hearing loss is experienced by one-third of individuals aged 65Â years and older and can be socially debilitating. Historically, there has been poor correlation between age-related threshold changes, loss of speech understanding, and loss of cochlear hair cells. We examined changes in ribbon synapse number at four different ages in Fisher Brown Norway rats, an extensively studied rat model of aging. In contrast to previous work in mice/Wistar rats, we found minimal ribbon synapse loss before 20Â months, with significant differences in 24- and 28-month-old rats at 4Â kHz. Significant outer HC loss was observed at 24 and 28 months in low- to mid-frequency regions. Age-related reductions in auditory brainstem response wave I amplitude and increases in threshold were strongly correlated with ribbon synapse loss. Wave V/I ratios increased across age for click, 2, 4, and 24Â kHz. Together, we find that ribbon synapses in the Fisher Brown Norway rat cochlea show resistance to aging until â¼60% of their life span, suggesting species/strain differences may underpin decreased peripheral input into the aging central processor.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 62, February 2018, Pages 53-63
Journal: Neurobiology of Aging - Volume 62, February 2018, Pages 53-63
نویسندگان
Rui Cai, Scott C. Montgomery, Kaley A. Graves, Donald M. Caspary, Brandon C. Cox,