کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6803500 | 1433544 | 2016 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Maternal dementia age at onset in relation to amyloid burden in non-demented elderly offspring
ترجمه فارسی عنوان
سن دمانس مادر در شروع در ارتباط با بار آمیلوئید در فرزندان سالخوردگی غیر متعصب
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Family history (FH) of dementia is a major risk factor for Alzheimer's disease, particularly when the FH is maternal and when the age of dementia onset (AO) is younger. This study tested whether brain amyloid-beta deposition, measured in vivo with 11C-Pittsburgh compound B (PiB), was associated with parental dementia and/or younger parental AO. Detailed FH and positron emission tomography (PiB) data were acquired in 147 nondemented aging individuals (mean age 75 ± 8). No participant had both positive maternal and paternal FH. A series of analyses revealed that those with maternal, but not paternal, FH had greater levels of PiB retention in a global cortical region than those without FH. PiB retention in maternal FH was not significantly greater than paternal FH. Younger maternal dementia AO was related to greater PiB retention in offspring, whereas younger paternal dementia AO was not. Overall, results suggest that not only is amyloid-beta burden greater in individuals with maternal FH, but also that the burden is greater in association with younger maternal AO.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 40, April 2016, Pages 61-67
Journal: Neurobiology of Aging - Volume 40, April 2016, Pages 61-67
نویسندگان
Jacqueline E. Maye, Rebecca A. Betensky, Christopher M. Gidicsin, Joseph Locascio, J. Alex Becker, Lesley Pepin, Jeremy Carmasin, Dorene M. Rentz, Gad A. Marshall, Deborah Blacker, Reisa A. Sperling, Keith A. Johnson,