کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6803673 | 1433547 | 2016 | 33 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Association of body mass index and the depletion of nigrostriatal dopamine in Parkinson's disease
ترجمه فارسی عنوان
ارتباط شاخص توده بدنی و کاهش دپامین نگروستریاتال در بیماری پارکینسون
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کلمات کلیدی
بیماری پارکینسون، شاخص توده بدن، فعالیت حمل و نقل دوپامین،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Several antecedent studies had reported close relationship between low body weight and Parkinson's disease (PD). However, there have been few investigations about the role of body weight to nigrostriatal dopaminergic neurodegeneration. This study enrolled 398 de novo patients with PD whom underwent [18F] N-(3-Fluoropropyl)-2β-carbon ethoxy-3β-(4-iodophenyl) nortropane positron emission tomography scan and body mass index (BMI) measurement. The relationships between BMI and dopamine transporter (DAT) activity were analyzed using linear regression analysis. A multivariate analysis adjusted for age, gender, disease duration, smoking status, coffee and tea consumption, and residence area revealed that BMI remained independently and significantly associated with DAT activity in all striatal subregions. Moreover, multiple logistic regression analyses showed that BMI was a significant predictor for the lowest quartile of DAT activity in the anterior putamen, ventral striatum, caudate nucleus, and total striatum. The present findings suggest that a low BMI might be closely associated with low density of nigrostriatal dopaminergic neurons in PD, which could support the evidence for the role of low body weight to PD-related pathologies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 38, February 2016, Pages 197-204
Journal: Neurobiology of Aging - Volume 38, February 2016, Pages 197-204
نویسندگان
Jae Jung Lee, Jungsu S. Oh, Jee H. Ham, Dong H. Lee, Injoo Lee, Young H. Sohn, Jae S. Kim, Phil Hyu Lee,