کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6803890 | 1433551 | 2015 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Total MRI load of cerebral small vessel disease and cognitive ability in older people
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کلمات کلیدی
white matter hyperintensities - ابررایانه ماده سفیدMRI - امآرآی یا تصویرسازی تشدید مغناطیسیCerebrovascular disease - بیماری عروق مغزیCerebral small vessel disease - بیماری عروق کوچک مغزیLacunes - شکافPerivascular spaces - فضاهای PerivascularCerebral microbleeds - میکروب های مغزیCognitive aging - پیری شناختی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Cerebral small vessel disease (SVD) may cause cognitive dysfunction. We tested the association between the combined presence of magnetic resonance imaging (MRI) features of SVD and cognitive ability in older age. Cognitive testing and brain MRI were performed in 680 older participants. MRI presence of lacunes, white matter hyperintensities, microbleeds, and perivascular spaces were summed in a score of 0-4 representing all SVD features combined. We also applied latent variable modeling to test whether the 4 MRI features form a unitary SVD construct. The SVD score showed significant associations with general cognitive ability. Latent variable modeling indicated that the 4 MRI markers formed a unitary construct, which showed consistent associations with cognitive ability compared with the SVD score. Total MRI load of SVD is associated with lower general cognitive ability in older age. The total SVD score performed consistently with the more complex latent variable model, suggesting validity and potential utility in future research for determining total SVD load.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 36, Issue 10, October 2015, Pages 2806-2811
Journal: Neurobiology of Aging - Volume 36, Issue 10, October 2015, Pages 2806-2811
نویسندگان
Julie Staals, Tom Booth, Zoe Morris, Mark E. Bastin, Alan J. Gow, Janie Corley, Paul Redmond, John M. Starr, Ian J. Deary, Joanna M. Wardlaw,