کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6804230 | 1433555 | 2015 | 17 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Characterizing human vestibular sensory epithelia for experimental studies: new hair bundles on old tissue and implications for therapeutic interventions in ageing
ترجمه فارسی عنوان
تشخیص اپیتلیال حسی وستیبولار انسانی برای مطالعات تجربی: بسته شدن موهای جدید بر روی بافت های قدیمی و پیامدهای آن برای مداخلات درمانی در پیری
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Balance disequilibrium is a significant contributor to falls in the elderly. The most common cause of balance dysfunction is loss of sensory cells from the vestibular sensory epithelia of the inner ear. However, inaccessibility of inner ear tissue in humans severely restricts possibilities for experimental manipulation to develop therapies to ameliorate this loss. We provide a structural and functional analysis of human vestibular sensory epithelia harvested at trans-labyrinthine surgery. We demonstrate the viability of the tissue and labeling with specific markers of hair cell function and of ion homeostasis in the epithelium. Samples obtained from the oldest patients revealed a significant loss of hair cells across the tissue surface, but we found immature hair bundles present in epithelia harvested from patients >60Â years of age. These results suggest that the environment of the human vestibular sensory epithelium could be responsive to stimulation of developmental pathways to enhance hair cell regeneration, as has been demonstrated successfully in the vestibular organs of adult mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 36, Issue 6, June 2015, Pages 2068-2084
Journal: Neurobiology of Aging - Volume 36, Issue 6, June 2015, Pages 2068-2084
نویسندگان
Ruth R. Taylor, Daniel J. Jagger, Shakeel R. Saeed, Patrick Axon, Neil Donnelly, James Tysome, David Moffatt, Richard Irving, Peter Monksfield, Chris Coulson, Simon R. Freeman, Simon K. Lloyd, Andrew Forge,