کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6804259 | 1433555 | 2015 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Resting-state synchrony between the retrosplenial cortex and anterior medial cortical structures relates to memory complaints in subjective cognitive impairment
ترجمه فارسی عنوان
همسانی حالت درمانی بین قشر راتوسپنتنیال و ساختارهای قشر داخلی قدامی مربوط به شکایت حافظه در اختلالات شناختی ذهنی است
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Subjective cognitive impairment (SCI) is a clinical state characterized by subjective cognitive deficits without cognitive impairment. To test the hypothesis that this state might involve dysfunction of self-referential processing mediated by cortical midline structures, we investigated abnormalities of functional connectivity in these structures in individuals with SCI using resting-state functional magnetic resonance imaging. We performed functional connectivity analysis for 23 individuals with SCI and 30 individuals without SCI. To reveal the pathophysiological basis of the functional connectivity change, we performed magnetic resonance-diffusion tensor imaging. Positron emission tomography-amyloid imaging was conducted in 13 SCI and 15 nonSCI subjects. Individuals with SCI showed reduced functional connectivity in cortical midline structures. Reduction in white matter connections was related to reduced functional connectivity, but we found no amyloid deposition in individuals with SCI. The results do not necessarily contradict the possibility that SCI indicates initial cognitive decrements, but imply that reduced functional connectivity in cortical midline structures contributes to overestimation of the experience of forgetfulness.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 36, Issue 6, June 2015, Pages 2145-2152
Journal: Neurobiology of Aging - Volume 36, Issue 6, June 2015, Pages 2145-2152
نویسندگان
Fumihiko Yasuno, Hiroaki Kazui, Akihide Yamamoto, Naomi Morita, Katsufumi Kajimoto, Masafumi Ihara, Akihiko Taguchi, Kiwamu Matsuoka, Jun Kosaka, Toshihisa Tanaka, Takashi Kudo, Masatoshi Takeda, Kazuyuki Nagatsuka, Hidehiro Iida, Toshifumi Kishimoto,