کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6804271 1433555 2015 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Telomere dysfunction reduces microglial numbers without fully inducing an aging phenotype
ترجمه فارسی عنوان
اختلال تلومر باعث کاهش تعداد میکروگلیال ها می شود بدون اینکه کاملا فنوتیپ پیری ایجاد شود
کلمات کلیدی
سلام، پیری تکراری، یادگیری فضایی، آپوپتوز سلولی، خنک کننده نوری، نمونه برداری جهانی فضایی،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی
The susceptibility of the aging brain to neurodegenerative disease may in part be attributed to cellular aging of the microglial cells that survey it. We investigated the effect of cellular aging induced by telomere shortening on microglia by the use of mice lacking the telomerase RNA component (TERC) and design-based stereology. TERC knockout (KO) mice had a significantly reduced number of CD11b+ microglia in the dentate gyrus. Because of an even greater reduction in dentate gyrus volume, microglial density was, however, increased. Microglia in TERC KO mice maintained a homogenous distribution and normal expression of CD45 and CD68 and the aging marker, ferritin, but were morphologically distinct from microglia in both adult and old wild-type mice. TERC KO mice also showed increased cellular apoptosis and impaired spatial learning. Our results suggest that individual microglia are relatively resistant to telomerase deficiency during steady state conditions, despite an overall reduction in microglial numbers. Furthermore, telomerase deficiency and aging may provide disparate cues leading to distinct changes in microglial morphology and phenotype.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 36, Issue 6, June 2015, Pages 2164-2175
نویسندگان
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