کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6804315 | 1433556 | 2015 | 62 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Inhibition of clathrin-mediated endocytosis prevents amyloid β-induced axonal damage
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
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چکیده انگلیسی
Amyloid β (Aβ)-induced axonal degeneration is a major cause of Alzheimer's disease (AD) pathology. However, the critical target to prevent Aβ-induced axonal degeneration remains unknown. Here, we analyzed growth cone collapse elicited by Aβ, a putative early Aβ-induced event in axons. Although no study has yet shown influence of Aβ on the growth cone, we first visualized Aβ-initiated growth cone collapse in cultured neurons. Furthermore, we determined that the collapse was triggered by clathrin-mediated endocytosis probably via Aβ-Ca2+ signaling. The inhibition of clathrin-mediated endocytosis prevented Aβ-induced axonal loss both in vitro and in vivo and prevented memory impairment in an AD mouse model. Our results clarified the important role of clathrin-mediated endocytosis in Aβ-induced collapse of growth cone that leads to axonal degeneration and memory impairment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 36, Issue 5, May 2015, Pages 1808-1819
Journal: Neurobiology of Aging - Volume 36, Issue 5, May 2015, Pages 1808-1819
نویسندگان
Tomoharu Kuboyama, Young-A. Lee, Hiroaki Nishiko, Chihiro Tohda,