کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6804721 1433558 2015 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evidence of an association between sleep and levodopa-induced dyskinesia in an animal model of Parkinson's disease
ترجمه فارسی عنوان
شواهد ارتباط بین دیسکینزی ناشی از خواب و لوودوپا در یک مدل حیوانی از بیماری پارکینسون
کلمات کلیدی
بیماری پارکینسون، دیسکینزی ناشی از لوودوپا، خواب هومئوستاز سیناپتیس، فعالیت ناگهانی موج،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی
Levodopa-induced dyskinesia (LID) represents a major challenge for clinicians treating patients affected by Parkinson's disease (PD). Although levodopa is the most effective treatment for PD, the remodeling effects induced by disease progression and the pharmacologic treatment itself cause a narrowing of the therapeutic window because of the development of LID. Although animal models of PD provide strong evidence that striatal plasticity underlies the development of dyskinetic movements, the pathogenesis of LID is not entirely understood. In recent years, slow homeostatic adjustment of intrinsic excitability occurring during sleep has been considered fundamental for network stabilization by gradually modifying plasticity thresholds. So far, how sleep affects on LID has not been investigated. Therefore, we measured synaptic downscaling across sleep episodes in a parkinsonian animal model showing dyskinetic movements similar to LID. Our electrophysiological, molecular, and behavioral results are consistent with an impaired synaptic homeostasis during sleep in animals showing dyskinesia. Accordingly, sleep deprivation causes an anticipation and worsening of LID supporting a link between sleep and the development of LID.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 36, Issue 3, March 2015, Pages 1577-1589
نویسندگان
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