کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6804731 | 1433559 | 2015 | 16 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Oleuropein aglycone protects against pyroglutamylated-3 amyloid-Ã toxicity: biochemical, epigenetic and functional correlates
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Oleuropein aglycone protects against pyroglutamylated-3 amyloid-Ã toxicity: biochemical, epigenetic and functional correlates Oleuropein aglycone protects against pyroglutamylated-3 amyloid-Ã toxicity: biochemical, epigenetic and functional correlates](/preview/png/6804731.png)
چکیده انگلیسی
Amyloid-Ã (AÃ) fragments, oligomeric AÃ aggregates, and pyroglutamylated-AÃ peptides, as well as epigenetic mechanisms and autophagy dysfunction all appear to contribute in various ways to Alzheimer's disease progression. We previously showed that dietary supplementation of oleuropein aglycone, a natural phenol abundant in the extra virgin olive oil, can be protective by reducing AÃ42 deposits in the brain of young and middle-aged TgCRND8 mice. Here, we extended our study to aged TgCRND8 mice showing increased pE3-AÃ in the brain deposits. We report that oleuropein aglycone is active against glutaminylcyclase-catalyzed pE3-AÃ generation reducing enzyme expression and interferes both with AÃ42 and pE3-AÃ aggregation. Moreover, the phenol astonishingly activates neuronal autophagy even in mice at advanced stage of pathology, where it increases histone 3 and 4 acetylation, which matches both a decrease of histone deacetylase 2 expression and a significant improvement of synaptic function. The occurrence of these functional, epigenetic, and histopathologic beneficial effects even at a late stage of the pathology suggests that the phenol could be beneficial at the therapeutic, in addition to the prevention, level.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 36, Issue 2, February 2015, Pages 648-663
Journal: Neurobiology of Aging - Volume 36, Issue 2, February 2015, Pages 648-663
نویسندگان
Ilaria Luccarini, Cristina Grossi, Stefania Rigacci, Elisabetta Coppi, Anna Maria Pugliese, Daniela Pantano, Giancarlo la Marca, Teresa Ed Dami, Andrea Berti, Massimo Stefani, Fiorella Casamenti,