کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6805104 | 1433560 | 2015 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Parkinson's disease and local atrophy in subcortical nuclei: insight from shape analysis
ترجمه فارسی عنوان
بیماری پارکینسون و آتروفی موضعی در هسته های زیرکوریک: بینش از تجزیه و تحلیل شکل
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Parkinson's disease (PD) is characterized by loss of dopaminergic neurons in the substantia nigra pars compacta, inducing dopaminergic depletion in the striatum. Recently, subcortical nuclei shape analysis based on T1 imaging has been used in PD pathology. The present study aimed to test the hypothesis that changes in local volume detectable with T1-weighted imaging are concomitant with PD and may be used as biomarkers. We compared 21 PD patients and 20 control subjects using gray matter density and subcortical nuclei volume and shape. We also tested correlations between these parameters and clinical scales. A linear discriminant analyses was carried out using global volume and local atrophy. The differences revealed between the 2 groups were volume differences in the putamen and shape differences in the putamen and the caudate nucleus. A correlation was found between shape and motor symptoms. The discriminant analysis performed using local atrophy values led to the best classification. Our results show that shape analysis contributes valuable information to investigations concerning PD patients and helps to discriminate these patients from control subjects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 36, Issue 1, January 2015, Pages 424-433
Journal: Neurobiology of Aging - Volume 36, Issue 1, January 2015, Pages 424-433
نویسندگان
Federico Nemmi, Umberto Sabatini, Olivier Rascol, Patrice Péran,