کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6805350 | 1433563 | 2014 | 28 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Use of diuretics is associated with reduced risk of Alzheimer's disease: the Cache County Study
ترجمه فارسی عنوان
استفاده از دیورتیک ها با کاهش خطر ابتلا به بیماری آلزایمر همراه است
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کلمات کلیدی
داروهای ضد فشار خون، دیورتیک ها، بیماری آلزایمر،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Although the use of antihypertensive medications has been associated with reduced risk of Alzheimer's disease (AD), it remains unclear which class provides the most benefit. The Cache County Study of Memory Health and Aging is a prospective longitudinal cohort study of dementing illnesses among the elderly population of Cache County, Utah. Using waves I to IV data of the Cache County Study, 3417 participants had a mean of 7.1 years of follow-up. Time-varying use of antihypertensive medications including different class of diuretics, angiotensin converting enzyme inhibitors, β-blockers, and calcium channel blockers was used to predict the incidence of AD using Cox proportional hazards analyses. During follow-up, 325 AD cases were ascertained with a total of 23,590 person-years. Use of any antihypertensive medication was associated with lower incidence of AD (adjusted hazard ratio [aHR], 0.77; 95% confidence interval [CI], 0.61-0.97). Among different classes of antihypertensive medications, thiazide (aHR, 0.7; 95% CI, 0.53-0.93), and potassium-sparing diuretics (aHR, 0.69; 95% CI, 0.48-0.99) were associated with the greatest reduction of AD risk. Thiazide and potassium-sparing diuretics were associated with decreased risk of AD. The inverse association of potassium-sparing diuretics confirms an earlier finding in this cohort, now with longer follow-up, and merits further investigation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 35, Issue 11, November 2014, Pages 2429-2435
Journal: Neurobiology of Aging - Volume 35, Issue 11, November 2014, Pages 2429-2435
نویسندگان
Yi-Fang Chuang, John C.S. Breitner, Yen-Ling Chiu, Ara Khachaturian, Kathleen Hayden, Chris Corcoran, JoAnn Tschanz, Maria Norton, Ron Munger, Kathleen Welsh-Bohmer, Peter P. Zandi, For the Cache County Investigators For the Cache County Investigators,