کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6805351 | 1433562 | 2014 | 31 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Trajectories of inflammatory markers and cognitive decline over 10 years
ترجمه فارسی عنوان
مسیرهای نشانگرهای التهابی و کاهش شناختی بیش از 10 سال
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
We aimed to examine trajectories of inflammatory markers and cognitive decline over 10Â years. Cox proportional hazards models were used to examine the association between interleukin-6 and C-reactive protein (CRP) trajectory components (slope, variability, and baseline level) and cognitive decline among 1323 adults, aged 70-79Â years in the Health, Aging, and Body Composition Study. We tested for interactions by sex and apolipoprotein E (APOE) genotype. In models adjusted for multiple covariates and comorbidities, extreme CRP variability was significantly associated with cognitive decline (hazard ratio [HR] 1.6, 95% confidence interval [CI]: 1.1-2.3). This association was modified by sex and APOE e4 (p < 0.001 for both), such that the association remained among women (HRÂ = 1.8; 95% CI: 1.1, 3.0) and among those with no APOE e4 allele (HRÂ = 1.6; 95% CI: 1.1, 2.5). There were no significant associations between slope or baseline level of CRP and cognitive decline nor between interleukin-6 and cognitive decline. We believe CRP variability likely reflects poor control of or greater changes in vascular or metabolic disease over time, which in turn is associated with cognitive decline.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 35, Issue 12, December 2014, Pages 2785-2790
Journal: Neurobiology of Aging - Volume 35, Issue 12, December 2014, Pages 2785-2790
نویسندگان
Andrea L. Metti, Kristine Yaffe, Robert M. Boudreau, Eleanor M. Simonsick, Ryan M. Carnahan, Suzanne Satterfield, Tamara B. Harris, Hilsa N. Ayonayon, Caterina Rosano, Jane A. Cauley, Health ABC Study Health ABC Study,