کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6806784 | 1433577 | 2013 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Exceptional memory performance in the Long Life Family Study
ترجمه فارسی عنوان
عملکرد حافظه فوق العاده در مطالعه خانواده طولانی زندگی
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کلمات کلیدی
مطالعه طولانی زندگی خانوادگی، حافظه بی نظیر، صفات کمی، انواع ژنتیکی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Research to understand variability at the highest end of the cognitive performance distribution has been scarce. Our aim was to define a cognitive endophenotype based on exceptional episodic memory (EM) performance and to investigate familial aggregation of EM in families from the Long Life Family Study (LLFS). Using a sample of 1911 nondemented offspring of long-lived probands, we created a quantitative phenotype, EM (memory z ⥠1.5), and classified LLFS families as EM and non-EM families based on the number of EM offspring. We then assessed differences in memory performance between LLFS relatives in the parental generation of EM families and those in non-EM families using multivariate analysis adjusted for APOE Apolipoprotein E genotype. LLFS relatives in the proband generation from EM families showed better EM performance than those from non-EM families (β = 0.74, standard error = 0.19, p = 1.4 à 10â4). We demonstrated that there is a familial correlation of the EM endophenotype, suggesting that genetic variants might influence memory performance in long-lived families.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Aging - Volume 34, Issue 11, November 2013, Pages 2445-2448
Journal: Neurobiology of Aging - Volume 34, Issue 11, November 2013, Pages 2445-2448
نویسندگان
Sandra Barral, Stephanie Cosentino, Rosann Costa, Stacey L. Andersen, Kaare Christensen, John H. Eckfeldt, Anne B. Newman, Thomas T. Perls, Michael A. Province, Evan C. Hadley, Winifred K. Rossi, Richard Mayeux,